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KMID : 0604520100360020115
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Journal of the Society of Cosmetic Scientists of Korea
2010 Volume.36 No. 2 p.115 ~ p.120
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Synergistic Effects of N-methyl-2-pyrrolidone on Skin Permeation of a Hydrophobic Active Ingredient
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Lee Geun-Soo
Lee Dong-Hwan
Kim Kyoung-Bum
Ko Hyun-Joo
Pyo Hyeong-Bae
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Abstract
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The formidable barrier property of the stratum cornemum and the high hydrophilicity of active ingredient make it difficult to permeate through the skin and reach to its site of action. The aim of this study was to investigate the effect of chemical penetration enhancers on the skin permeation of a hydrophilic cosmetic active ingredient, such as arbutin. The enhancing effects of N-methyl-2-pyrrolidone (NMP) on the permeation of a hydrophilic cosmetic active ingredient were evaluated by using Franz diffusion cell. The study indicated that NMP has considerable influence on the skin permeability. NMP was not only the most effective enhancer but also increased the skin permeability of arbutin approximately 1.3~1.5 fold compared with control without penetration enhancer. The lag time did not change with NMP, which suggested no effect of NMP on skin lipid fluidity. This suggest that arbutin co-permeated with NMP. The results indicate NMP is effective enhancer of a hydrophilic cosmetic active ingredient in penetration, with potential applications for drug delivery system.
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KEYWORD
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N-methyl-2-pyrrolidone, enhancement ratio, cosmetic, hydrophobic active ingredient
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